The Current Situation of Long COVID Treatment

There is currently no cure for Long COVID, nor FDA approved treatments. This means that, for the most part, safety and efficacy of long COVID treatments is poorly understood. Most professionals in the field recommend rehabilitation, symptom management, and seeking help from professionals in their respective fields (e.g. Pulmonologist for breathing issues). 

However there is emerging evidence that certain supplements and medications can alleviate symptoms and/or attack the speculated root causes of Long COVID.

The effectives of treatments is likely to differ between people.

Revover Long Covid

General Health and Anti-Inflammatory Support (The Basics)

General Health Protocol
Always
Pacing
Prevent crashes, let your body recover

Empty Stomach / Morning

NAD+ Supplement
250–500 mg NMN or 250–300 mg NR
Nattokinase
100–200 mg or 2,000–4,000 FU
Creatine
3–5 g

After Lunch

Multivitamin
Correct deficiencies, especially D
Omega-3
Correct deficiency, 1–2 g
Garlic
1 g extract
Vitamin C
1500 mg
Pro & Prebiotics
Correct imbalance, up to 1 natural source / day

Notes for the Basic Protocol

This protocol is meant as a foundational support system for improving general health and managing low-level inflammation, and recovery from viral infections.

The best practice would be to tailor your dosage based on blood tests (correcting deficiencies) and response to the supplements.

Generally Effective Additions

Generally Effective Additions

Morning

Citicoline
500–2000 mg
Baicalin
300 mg
Hesperidin
500 mg

After Lunch

Aspirin
80 mg

Any Time

Rapamycin
Dosing in notes
LDN
Dosing in notes
Apheresis
Frequency in notes

Notes for the Additions

This section includes treatments with broad therapeutic potential for Long COVID. These interventions have supportive scientific evidence and may be added to your protocol for additional benefit, but are non-essential, unlike nutrients, such as vitamins.

Rapamycin and LDN are prescription medications and can only be taken under the supervision of a medical professional. To learn more about their dosing, please visit the individual treatment pages. Apheresis is also an intensive procedure, which can only be guided by a professional.

Targeted Additions by Need

PEM | Fatigue
NAD+
250–500 mg NMN or 250–300 mg NR / Day; Otherwise - intravenous (Doctor guided dosing, stronger effect)
Creatine3–5 g / day
HBOTSeveral / week
Red Light TherapyOnce / day
Notes: The 3 secondary options are likely to be significantly less effective than IV NAD+.
Brain Fog | Memory | Dizzines
Citicoline
500-2000 mg / Day
PEA300–1200 mg / Day
Melatonin0.5–5 mg / Day
Notes: These are likely to have a mild effect, depending on the person.
POTS | Cardiovascular
Rx Beta Blockers
Doctor guided
Fluids & ElectrolytesCorrecting deficiencies
Compression stockingsDaytime
Notes: Rx Beta Blockers and similar medications will have the biggest effect, although they are more likely to have side effects. However, it is a good idea to try non-pharmaceutical interventions first.
Sleep
Rx Sleep Medications
Doctor guided
Melatonin0.5–5 mg / Day
Notes: It is a good idea to try melatonin up to 5 mg before attempting Rx medications. They are likely to be effective but also carry a higher risk of side effects.
Breathing | Loss of Smell
PEA
300-1200 mg / Day
Notes: Treating loss of smell largery overlaps with treatments in the Braing Fog / Neurological category.
Fibrinogen | D-dimer | PT/INR | vWF
Nattokinase
100–200 mg or 2,000–4,000 FU / Day
Aspirin80 mg / day
ApheresisDoctor guided
Notes: Indicates blood clotting and potentially vascular damage. Some other tests: Activated Partial Thromboplastin Time (aPTT), Platelet Count (part of CBC), Thromboelastography (TEG), Rotational Thromboelastometry (ROTEM), Antithrombin III, Protein C Activity, Protein S Activity, Lupus Anticoagulant, Antiphospholipid Antibodies, von Willebrand Factor, Plasminogen Activator Inhibitor-1 (PAI-1), Tissue Plasminogen Activator (tPA). Read more in the Mechanisms > Blood Clots section.
SARS-CoV 2 Spike Protein | Spike Antibody
Antivirals
Doctor guided
Hesperidin500 mg / Day
Baicalin300 mg / Day
AHCC1-3 g / Day
Garlic (Allicin)1 g extract / Day
Notes: SARS-CoV-2 Spike, antibody, and specific T-Cell activation blood tests may identify persistent virus, but not with 100% accuracy. Antibody tests may also suggest a past (not ongoing) infection. Antivirals, like Paxlovid are likely to have a larger effect, but it is a good idea to try the alternatives before moving on to stronger medications, because they have a higher chance of side effects.
CRP | Interleukins | TNF | ESR
Rapamycin
Dosing in notes
Apheresis1 - 2 / Week
Hesperidin500 mg / Day
Baicalin300 mg / Day
Vagal Nerve StimulationDoctor guided
Notes:Indicates inflammation. Other tests: LDH, Albumin, Interferon-gamma, CXCL10, Neopterin, HMGB1, CBC with differential, NLR (neutrophil-to-lymphocyte ratio), sCD14, sCD163, ANA. Read more about treatments in the Mechanisms > Chronic Inflammation section.
Persistent Virus
Antivirals
Doctor guided
Hesperidin500 mg / Day
Baicalin300 mg / Day
AHCC1-3 g / Day
Garlic (Allicin)1 g extract / Day
Notes: Antivirals, like Paxlovid are likely to have a larger effect, but it is a good idea to try the alternatives before moving on to stronger medications, because they have a higher chance of side effects.
Chronic Inflammation
Rapamycin
Dosing in notes
ApheresisDoctor guided
Hesperidin500 mg / Day
Baicalin300 mg / Day
Vagal Nerve StimulationDoctor guided
Notes: Rapamycin can have profound effect on the entire spectrum of Long COVID symptoms in some people, but the effect may be limited to as long as you're using it. Response varies between individuals, the effect may stay long term. For dosing information, visit the individual treatment page. It is a prescription medication. There are a lot of anti-inflammatory treatments, which could not fit here, visit the treatments page to learn more.
Blood Clotting
Nattokinase
100–200 mg or 2,000–4,000 FU / Day
Aspirin80 mg / day
ApheresisDoctor guided
Notes: Apheresis is an intensive procedure that can use up a lot of calories in a short span of time, however it's relatively safe. It can only be done under the supervision of a professional.
Autoimmunity
Intravenous Immunoglobulin
Doctor guided
Notes: Intravenous Immunoglobulin therapy is used to target Antibodies that attack your own tissues. It is only guided by a professional and done when Autoantibody blood tests are positive.
Other Reactivated Viruses
Antivirals
Doctor guided
Hesperidin500 mg / Day
Baicalin300 mg / Day
AHCC1-3 g / Day
Garlic (Allicin)1 g extract / Day
Notes: The treatments are largely the same as for persistent SARS-CoV-2. Antiviral choice may depend on the type of virus reactivated. Blood tests can identify these reactivations.
Mitochondrial Dysfunction
NAD+
250–500 mg NMN or 250–300 mg NR / Day; Otherwise - intravenous (Doctor guided dosing, stronger effect)
Creatine3–5 g / day
HBOTSeveral / week
Red Light TherapyOnce / day
Notes: The treatments here are largely the same as PEM and Exhaustion treatments.

Notes for the Targeted Additions

This section organizes additional treatments based on three categories to help personalize your protocol:

By Symptoms – The most accessible category, used to alleviate the symptoms you experience. Useful if you’re unsure where to start.

By Blood Tests – These additions target abnormalities identified through lab results. Use this if you have empirical data from blood work.

By Mechanism – Treatments are grouped by their proposed biological mechanisms and are largely aimed at ending the illness altogether. These are more theoretical and may require a deeper understanding of Long COVID.

For each entry, the first treatment is considered the most effective or best supported. The other options are second-line alternatives or complementary treatments if needed. However, it is a good idea to start with less aggressive treatments and see your reaction.