What Are Nattokinase and Lumbrokinase?
Nattokinase and lumbrokinase are fibrinolytic enzymes, meaning they help break down
fibrin, a protein involved in blood clot formation. Nattokinase is derived from natto, a
fermented soybean dish, while lumbrokinase comes from earthworms. Both have been
studied for their potential to improve circulation, reduce clotting abnormalities, and
removing lingering virus particles.
How Nattokinase and Lumbrokinase Help for Long COVID
- Breaking Down Microclots: Research has shown that long COVID patients often
have persistent microclots (tiny, resistant blood clots that can impair circulation) that may contribute to symptoms like fatigue, cognitive impairment, and shortness of breath. Nattokinase and lumbrokinase have demonstrated the ability to degrade these abnormal clots, improving blood flow and oxygen delivery. - Degrading Spike Protein: Studies suggest that nattokinase and lumbrokinase
can break down the SARS-CoV-2 spike protein, which has been detected in long
COVID patients months after infection or vaccination. Eliminating persistent spike
protein contributed to reducing inflammation and alleviating symptoms.
What the Research Says
Studies suggest that fibrinolytic enzymes like nattokinase and lumbrokinase could help
manage long COVID symptoms by targeting microclots and persitent spike proteins.
Key Studies on Nattokinase and Lumbrokinase for Long COVID
Articles discussing theoretical benefits:
- A study used automated microscopic measurement to confirm the presence of
abnormal fibrinaloid microclots in long COVID patients. The study found that
nattokinase effectively degrades these microclots. - A report highlights the strong fibrinolytic properties of lumbrokinase, suggesting
that it could aid in breaking down persistent clots and improving circulation in
long COVID patients. - Research from multiple sources, including a scoping review, suggests that
nattokinase may help break down the SARS-CoV-2 spike protein, which has
been detected in long COVID patients long after the initial infection or vaccination.
This could be a key mechanism by which nattokinase supports recovery. - A review and a clinical rationale study propose nattokinase, bromelain, and
curcumin as part of a regimen to help clear lingering spike protein and reduce
inflammation in long COVID patients. - A research article explores how proteolytic enzymes like nattokinase and
bromelain can degrade spike protein, suggesting that these compounds may aid
in detoxification efforts for individuals with post-COVID and vaccine-related
symptoms. - A trial (NCT06511050) is currently investigating the effect of 300.000 FUs of lumbrokinase twice daily on long COVID recovery.
Final Thoughts and Typical Use
Nattokinase and lumbrokinase offer promising potential for long COVID recovery, particularly for those experiencing circulatory issues and persistent inflammation. While specific dosing for nattokinase or lumbrokinase in long COVID has not been formally established, these enzymes are commonly used to support circulatory health and fibrin breakdown in other clot-related conditions. A typical dose of nattokinase is 100–200 mg daily, providing around 2,000–4,000 FU, usually taken on an empty stomach. For lumbrokinase, clinical use often involves 20–60 mg daily. As with any supplement, it is crucial to consult a healthcare provider before starting nattokinase or lumbrokinase, especially for individuals on blood thinners or with clotting disorders.
